Abstract
A fifty-year-old male was admitted with the chief complaints of fever, jaundice, hemorrhagic tendency and fatigue.
Laboratory examinations revealed liver function abnormalities, slight anemia, leucopenia and marked thrombocytopenia; the bleeding time was over 18 minutes. Reticulum cells were seen in the smears of the peripheral blood. Several attempts of culture with arterial blood and bone marrow failed to grow any organism. A bone marrow study revealed that 28.8 percent consisted of the reticulum cells with the particular morphological appearance of form cells. A lymph node biopsy specimen disclosed the picture of sinus reticulosis.
Vigorous treatments failed to save his life and the autopsy was performed: It showed generalized lymphadenopathy and the granulomatous proliferations in the liver, spleen and bone marrow. Histologically the reactive proliferation of reticulum cells was observed in these organs.
This case does not appear to correspond to any clinical entity of reticulosis thus far described. We have attempted to speculate on the etiology of reticulosis and referred to the similarities seen in this condition and the homologous disease.
