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Volume 11, Issue 1
Displaying 1-9 of 9 articles from this issue
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T. Abe1970 Volume 11 Issue 1 Pages 1-3
Published: 1970
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSDownload PDF (297K) -
[in Japanese], [in Japanese], [in Japanese]1970 Volume 11 Issue 1 Pages 4-20
Published: 1970
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSDownload PDF (1533K)
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Hiroshi NISHIYAMA, Kazuo OTA1970 Volume 11 Issue 1 Pages 21-29
Published: 1970
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSBased on the data obtained from the Annual of Pathological Autopsy Cases in Japan, published the period of 1958-66, 723 cases in which clinicians and pathologists failed to agree on a diagnosis of leukemia were analyzed in order to clarify the problems of accurately certifying the disease. The diversity of discrepant diagnoses against leukemia by both clinicians and pathologists must be a reflection of the exceedingly variable clinical and necropsy findings. An ascertainment of mis-diagnoses by either clinicians or pathologists is not feasible within the data available because of many instances without clearcut demarcation between leukemia and the related disorders. The discrepant diagnoses observed rather frequently are malignant lymphoma, aplastic anemia, septicemia, reticulosis and others. Clinicians appear to fail sometimes accurately certifying leukemia against tuberculosis, cancer of the stomach, and neuroblastoma, but pathologists' diagnoses of marrow hyperplasia and neuroblastoma, but pathologists' diagnoses of marrow hyperplasia and/or mycosis appear not sufficient counter-diagnoses, on the other hand. The observed results were discussed by reviewing literatures in the sense of differential diagnosis of leukemia of some controversial issues.View full abstractDownload PDF (711K) -
Matsuzo MATSUOKA, Tetsuya Ishida1970 Volume 11 Issue 1 Pages 30-37
Published: 1970
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSFive patients with myelofibrosis, including one case of secondary myelofibrosis with polycythemia vera were investigated clinically.
1. Age distribution ranged from 38 to 55 years. Three cases were female and two were male.
2. All patients showed similar clinical and laboratory findings to those reported by other authors.
3. Erythrocyte osmotic fragility was slightly increased in 4 cases.
4. Reduced glutathion (GSH) erythrocytes was increased in 5 cases. The elevated level of erythrocyte GSH was assumed to be resulted from an increased synthesis of GSH in erythrocytes of the extramedullary origin.
5. The determination of erythrocyte GSH and leukocyte alkaline phosphatase would be useful in differentiting myelofibrosis from chronic myelogenous leukemia.View full abstractDownload PDF (593K)
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Yoosuke MIYAGAWA, Tyen Po CHEN, Yasuhiko ANDO, Yasuhiko ITATSU1970 Volume 11 Issue 1 Pages 38-42
Published: 1970
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA 45-year-old male was admitted to the Keio University Hospital because of severe anemia. He was emaciated and slightly icteric. There was no lymphadenopathy or splenomegaly, but sternal tenderness was present and the liver edge was felt 2.5 fingerbreadths below the costal margin. On fundoscopy, right retinal hemorrhage was noticed.
Laboratory examination revealed severe normochromic anemia as well as thrombocytopenia. The leukocyte counts were normal. The blood film disclosed leukoerythroblastic picture with marked red cell fragmentation. The reticulocyte counts were elevated. Hemosiderin granules were detected in the urine. Sucrose hemolysis test and acidified serum test (Ham) were found positive. Indirect bilirubin, lactic acid dehydrogenase, alkaline phosphatase and serum iron were elevated.
Because of these laboratory data, a diagnosis of microangiopathic hemolytic anemia was made. The patient died of cerebral hemorrhage on the fourth hospital day despite of prednisolone therapy.
Autopsy revealed multiple mucosal cancer of the stomach with generalized metastases to lungs, mesenteric lymph nodes, liver and bone marrow. Careful microscopic observation could not demonstrate the presence of thrombotic microangiopathy or tumor cell thrombi.
The significance of the positive sucrose hemolysis test and acidified serum test was discussed.View full abstractDownload PDF (616K) -
Takashi NUNOKAWA, Mitsuo TANNO, Yasushi FUNATO, Hikoyuki SUZUKI, Kiyos ...1970 Volume 11 Issue 1 Pages 43-48
Published: 1970
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA fifty-year-old male was admitted with the chief complaints of fever, jaundice, hemorrhagic tendency and fatigue.
Laboratory examinations revealed liver function abnormalities, slight anemia, leucopenia and marked thrombocytopenia; the bleeding time was over 18 minutes. Reticulum cells were seen in the smears of the peripheral blood. Several attempts of culture with arterial blood and bone marrow failed to grow any organism. A bone marrow study revealed that 28.8 percent consisted of the reticulum cells with the particular morphological appearance of form cells. A lymph node biopsy specimen disclosed the picture of sinus reticulosis.
Vigorous treatments failed to save his life and the autopsy was performed: It showed generalized lymphadenopathy and the granulomatous proliferations in the liver, spleen and bone marrow. Histologically the reactive proliferation of reticulum cells was observed in these organs.
This case does not appear to correspond to any clinical entity of reticulosis thus far described. We have attempted to speculate on the etiology of reticulosis and referred to the similarities seen in this condition and the homologous disease.View full abstractDownload PDF (831K) -
Keiichi HASHIMOTO, Takayuki KANIE, Yutaka MIBUKURA, Hidemasa OKUMURA, ...1970 Volume 11 Issue 1 Pages 49-57
Published: 1970
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSR. H., a 58 aged housewife was admitted in our hospital on June 11, 1962, with complaints of photosensitivity, marked anemia, jaundice and hepato-splenomegaly. Laboratory findings revealed porphyrinuria, hyperchromic macrocytic anemia with myeloblastoid-cells in peripheral blood and megaloblastoid-cells in the bone marrow, marked increase of direct and inderect bilirubin, reticulocytosis, and shortened lifespan of erythrocytes. The liver damage was indicated by BSP retention, positive colloid reactions, and high serum level of GOT and GPT. Porphrin analysis revealed marked increase of protoporphyrin in erythrocytes, plasma, bone marrow and stool. A considerably large number of flourescing normoblasts were seen in bone marrow. The patient died of hepatic coma with pneumonia on January 10, 1965, after 3.5 years treatment by blood transfusion and various drugs, repeating improvement and aggravation of the symptoms. Autopsy studies showed hypoplasia of bone marrow with increased reticulum cells, hemosiderosis of liver and other organs, but there was no sign of leukemia. These findings indicated protoporphyria erythropoietica, which association with hemolytic anemia was reported only in two cases: those of Porter et al. and Masuya et al. In addition to that our case had myeloblastoid-cells in peripheral blood and megaloblastoid-cells in bone marrow for the first case on this line.View full abstractDownload PDF (765K) -
Hideo YAMADA, Izumi NAKASHIMA, Akiyasu YASUMA1970 Volume 11 Issue 1 Pages 58-65
Published: 1970
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSPure red cell aplasia was found in a patient (31-year-old man) with infectious hepatitis who was treated with chloramphenicol, 1500 mg daily for supposed infection of biliary tract. Bone marrow aspiration showed almost complete absence of erythroid cells with normal myeloid series and megakaryocytes.
There remained 3.6 percent of erythroid cells in bone marrow all of which were vacuolated primitive erythroblasts. There was a rapid and complete recovery after discontinuance of the drug. Ferrokinetics studies were performed before and after his hematological recovery.
In a review of the literature in Japan, we found five instances of pure red cell aplasia associated with chloramphenicol therapy. Five patients including our case recovered when the drug was removed.
Finally the pathogenetic mechanism for chloramphenicol-induced pure cell aplasia has been discussed on the basis of current literature.View full abstractDownload PDF (722K) -
Nobuyuki TAGUCHI, Takeshi ABE, Mutsuyoshi KAZAMA, Michio MATSUDA, Ryos ...1970 Volume 11 Issue 1 Pages 66-72
Published: 1970
Released on J-STAGE: October 31, 2008
JOURNAL RESTRICTED ACCESSA 5-year-old girl with congenital afibrinogenemia was reported. There was consanguinity of the parents, but no other member of the family was similarly affected.
Bleeding episodes of this patient were started with umbilical bleeding and accompanied by multiple bruises after trauma, but no hematuria and melena, nor spontaneous hemoarthrosis was seen.
Laboratory examinations revealed no specific abnormality except for delayed erythrocyte sedimentation rate. Liver function tests were within normal limits. Fibrinogen in the blood was not demonstrated by coagulative, physicochemical and immunological methods. Clotting factors other than fibrinogen were normal. Circulating anticoagulants and elevated plasma fibrinolytic activity were not demonstrated.View full abstractDownload PDF (559K)
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