Abstract
A 5-year-old girl with congenital afibrinogenemia was reported. There was consanguinity of the parents, but no other member of the family was similarly affected.
Bleeding episodes of this patient were started with umbilical bleeding and accompanied by multiple bruises after trauma, but no hematuria and melena, nor spontaneous hemoarthrosis was seen.
Laboratory examinations revealed no specific abnormality except for delayed erythrocyte sedimentation rate. Liver function tests were within normal limits. Fibrinogen in the blood was not demonstrated by coagulative, physicochemical and immunological methods. Clotting factors other than fibrinogen were normal. Circulating anticoagulants and elevated plasma fibrinolytic activity were not demonstrated.
