Abstract
Two cases, a 8-years-old boy and a 2-years-old girl, of thrombasthenia (Glanzmann type) were investigated on the aggregation of their platelets.
Although the aggregation by adding ADP on other agents such as collagen, serotonin and adrenalin did not occur in thrombasthenic platelets, only bovine fibrinogen was successful to induce the aggregation of their platelets.
Our results that rabbit fibrinogen failed to aggregate platelets, suggested that bovine fibrinogen was probably a unique one of the animal fibrinogens for human platelets aggregation.
In our studies, inhibitions for the aggregation by bovine fibrinogen were clearly observed in both thrombasthenic platelets and the platelets, which were obtained from healthy subjects and influenced by EDTA or TAMe.
These results indicate that these phenomena can be observed only under the deficiency or suppression of ADP aggregation. Additionally, it must be noted that the thrombasthenic platelets work fairly well in the observation of such a phenomenon.
