Abstract
Hemophilia and its related diseases are hereditary diseases of blood coagulation disorder. No abnormalities of sex and autosomal chromosomes have been reported in many cases of the above mentioned by the tissue culture method, but recently, Elves, Witkowski and others have reported anomaly of X-chromosome in few cases. Sex and autosomal chromosomes were analysed on cultures of leucocytes obtained from the peripheral blood on 12 cases of hemophilia A patient and 2 cases of its carriers, 4 cases of hemophilia B patient, one case of Factor VII deficiency patient and Factor X deficiency patient, a female von Willebrand's disease, and a blood coagulation disorder (Hemophilia A suspected). The following results were obtained: The counts of all cases analysed in this report indicated the normal modal number of 46 chromosomes in the range 90∼100 per cents.
The relative length, —the ratio to the total length of autosomal chromosomes— of X chromosomes in hemophilia A patients were in range 48∼53 (normal range 51∼58), but centromere index and arm ratio were in the normal range. Other chromosotmes were normal. X and autosomal chromosomes of hemophilia B patients were normal. The relative length of their Y chromosomes were in the range 26∼33, but their centromere index and arm ratio were normal.
Sex chromosomes of a factor VII deficiency patient, a factor X deficiency patient and a female von Willebrand's disease were normal, but it was interesting that the length of No. 6th of autosomal chromosome were longer than that of the normal subject.
