Abstract
The inhibition of plasmin system by 4-(2-carboxyethyl) phenyl-trans-4-aminomethyl cyclohexane carboxylate hydrochloride was studied in vitro, and compared with by Trasylol and AMCHA.
1. The substance was capable of an activity to inhibit both plasmin and plasminogen activation. A striking difference between DV 1006 and AMCHA was that the former inhibited casein digestion by plasmin, but the latter had essentially no effect. The caseinolysis induced by plasmin was inhibited competitively by DV 1006.
2. The AGLMe-lysis induced by urokinase was inhibited competitively by DV 1006 in 10-4M order and by AMCHA in 10-2M order. Trasylol had no effect on AGLMe-lysis by urokinase.
