Abstract
A 24-year-old man was diagnosed as hyperthyroidism and had been given mercazole 30 mgm. daily since January 1973. At the end of March 1973 pancytopenia was noticed in his peripheral blood, and he was referred to the Department of Hematology, Toranomon Hospital and admitted on March 30, 1973.
On admission hemoglobin was 7.0 Gm/100 ml, RBC 2,730,000 per cu. mm., hematocrit 22%, reticulocytes 0.8%, WBC 1,900 per cu. mm. with 4.5% myeloblasts with occasional Auer bodies and platelets 21,000 per cu. mm. The sternal marrow aspirate showed a hypercellular material with 63.0% atypical myeloblasts. Diagnosis of acute myeloblastic leukemia was made.
Blood group examination on admission revealed a weakly positive agglutination of the patinet's red cells against anti-A and negative against anti-A1 serum. In the reverse serum grouping, the patient's serum agglutinated only red cells of group B and no agglutination occurred against the red cells of groups A, O, and A1. A few years ago he was known to be of group A on a test at the blood bank. His father was of group O and mother of group A1.
After an intensive therapy a complete remission was obtained on June 16, 1973, when his blood group was diagnosed to be A1; this condition remained unchanged until May 1974.
