Abstract
The patient, a 71-year-old male, with erythroleukemia and multiple early cancers of the stomach was reported.
He visited his home doctor because of epigastralgia and was made a diagnosis of gastric cancer. Then he was referred to our hospital to receive an operation of gastric cancer. The peripheral blood findings on admission revealed anemia (RBC 1,610,000/mm3), leukocytosis (WBC 17,000/mm3, Blast 29%), and thrombocytopenia (40,000/mm3). Bone marrow examination revealed erythroid hyperplasia with megaloblastoid cell (3.2%) and PAS positive erythroblast (7%), and myelogenous leukemic change (atypical myeloblast 14.6%). The vitamin B12 level was normal. A polypoid cancer of pyloric antrum and an ulcerated cancer of gastric angle were found by gastroendoscopy and both biopsy-specimens showed adenocarcinoma tubulare. A diagnosis of erythroleukemia and of multiple early cancers of the stomach was made and a large amount of fresh blood, predonine (30 mg/day, per os) and 6MP (100 mg/day, per os) were administerted. After one month, his hematological findings were transformed to acute myelogenous leukemia. He was died, six months later.
The chief autopsy findings were as follows:
1) Myelogenous leukemic bone marrow.
2) Two gastric cancers, reaching to submucosa.
No metastasis was found in regional lymph nodes and the other organs.
