1974 Volume 15 Issue 9 Pages 1021-1027
Seven cases with acute promyelocytic leukemia were treated with Neocarzinostatin alone and concomitantly with other antileukemic agents.
A complete remission was obtained in 4 of 7 cases (57.1%).
The duration of complete remission was more than 14 months for the first case, 6 months for the third case and more than 3 months for the forth case. These cases had been treated with Neocarzinostatin in combination with other antileukemic agents. The duration of complete remission was 2 months and survival was 6 months for the second case who had been treated with Neocarzinostatin alone.
Whereas a complete remission was obtained in 2 of 13 cases (15.4%) for the groupe in which had been treated with antileukemic agents except for Neocarzinostatin.
It is conculuded that chemotherapy with Neocarzinostatin alone and concomitantly with other antileukemic agents seems excellent in induction of acute promyelocytic leukemia.
In leukemic cells enlargement and degeneration due to Neocarzinostatin treatment were observed light and electron microscopically.
