1974 Volume 15 Issue 9 Pages 1028-1035
Among congenital coagulation factor deficiencies, factor V deficiency is considered a very rare disease. It may be cited as one of the reasons that this disease is not easily found because it is accompanied by only slight hemorrhagic tendency.
Two cases of congenital factor V deficiency were presented. Case I had undergone three surgical operations and had no abnormalities in menstruation, and as diagnosed as this disease at the age of 55. She died of intracranial hemorrhage. Case 2 showed only a slight hemorrhagic tendency, having had only three bleeding episodes up to the age of 30, but was diagnosed as this disease because of the formation of deep hematomas. The factor V level was 2.7 and 6.4% in two cases. A genetic history was noted in Case I, but not in Case 2. No abnormalities were found in the other coagulation factor and fibrinolysis. Platelet function, especially a simple method for determining platelet factor I has also been described.
