Abstract
A case of 64-year-old man of chronic lymphocytic leukemia with IgM paraproteinemia was reported. He was admitted to our hospital with a complaint of general malaise. Physical examination showed generalized lymphadenopathy and splenomegaly. The initial hemogram revealed hemoglobin, 10.7 g/dl; hematocrit, 32%; platelet count, 66,000/mm3; white blood cell count, 33,800/mm3 with 87% mature lymphocytes. The bone marrow was characterized by a massive infiltration of mature small lymphocytes. Total serum protein was 8.2 g/dl, and paper electrophoresis showed a narrow peak in the fast γ region. Immunoelectrophoresis demonstrated an IgM-κ paraprotein. Individual immunoglobulin quantitation was as follows: IgG 2,000 mg/dl, IgA 498 mg/dl, and IgM 826 mg/dl. Urinary Bence Jones protein was negative. The patient has been followed without any specific treatment over a period of 20 months. Although some progression has occurred in the disease during this follow-up period, he is apparently leading a normal life.
