Abstract
Three cases of Ig-D myeloma were reported and seventy-nine cases of Japanese Ig-D myeloma in literature were reviewed on clinical manifestations and immunochemical features.
Male predominance, light chain λ predominance, high frequency of B-J proteinuria and renal dysfunction, and low level TTT and ZTT were characteristic in Ig-D myeloma. In the majority of cases, total protein levels were in normal range. No M-component or two spikes of M-component were frequently seen.
Age distribution, chief complaints, osteolytic lesions, extraosseous lesions, morphology of plasma cells, appearance of plasma cells in peripheral blood, and prognosis were similar to those in Imamura's report and Horikoshi's report in which all types of myloma in Japan have been included.
Median survival in our series were shorter than that of Jancelewicz's series, however it is still open to reevaluate because it is difficult to obtain accurate clinical courses from literature. Lymphadenopathy and hepatosplenomegaly whict have been adverted in Jancelewicz's report were considered not to be essential to Ig-D myeloma.
