Abstract
Against the life threatening infections in severe neutropenic patients (neutrophils <500/μl), neutrophils obtained by Haemonetics Model 30 from normal donors, were transfused to 26 cases (21 patients) on 80 occasions. An average of 10.9±8.3 (×109)/m2 neutrophils was administered per transfusion on every other day until the clearing of infections (1∼7 transfusions, mean: 3.1).
The mean of neutrophil increment was 322±347/μl.
Definite clinical improvement was noted in 21 cases (80.8%). Mild or moderate degree transfusion reactions were observed on 12 occasions (15%). These reactions were lessoned by slowing the infusion rate and by administering antihistaminics. Based on neutrophil transfusions, intractable leukemia can now be induced into remission with agressive chemotherapy.
