Abstract
In twenty-one patients with leukemia associated with DIC, levels of serum complement components (C1q, C1s, C3, C4, C3 anaphylatoxin, C5, C9 and factor B) were measured sequentially by single radial immunodiffusion method. The levels of C5, C9 and factor B on admission without DIC are significantly higher than those of normal control (p>0.05). The levels of C1q, C1s, C3 and C3 anaphylatoxin in DIC, which was diagnosed by high FDP (more than 20μg/ml) and low fibrinogen (less than 200 mg/dl) levels, are significantly lower than those of normal control (p<0.05). The lower the levels of C3, C4, C5 and factor B are, the worse the prognoses of patients—good parameters for prognosis. Therefore, it is of prognostic value to evaluate the levels of complement components especially C1q, C1s, C3 and C3 anaphylatoxin in DIC associated with leukemia.
