Abstract
Serum ferritin was examined by 2-site immunoradiometric assay in various hematological disorders which showed impaired erythropoiesis and received blood transfusion (BTF). Aplastic anemia (AA) and polycythemia vera which showed pancytopenia in the course of treatment revealed high serum ferritin concentration because of depressed erythropoiesis. Pernicious anemia (PA) and sideroblastic anemia (SA) also revealed high serum ferritin concentration because of ineffective erythropoiesis.
Also, it was clear that there was a close correlation between serum ferritin concentration in various hematological disorders (hemolytic anemia, AA. SA and various types of leukemia) and voluminous BTF.
It may be suggested that, in addition to impaired erythropoiesis and voluminous BTF, serum ferritin could be related to many other factors, e.g. bleeding, production by tumorcell, hepatocellular injury, infection etc., in complication with hematological diseases.
