Abstract
A 57-year-old male entered the Kochi Municipal Central Hospital on March 29, 1979 with cough, headach and joint pain. Physical examination revealed a liver enlarged to 3 cm below the costal margin. But there were neither splenomegaly nor lymphadenopathies. A diagnosis of multiple myeloma was made which was confirmed by the findings of plasma cells in the bone marrow. When attempts to obtain blood samples were made, there was a rapid gelation of it. This gelatinous blood clot did not retract at all, so no serum could be obtained even after centrifugation at 10,000 rpm. On histologic examination, this clot showed homogenious gelatinous appearance without evidence of a fibrin net. The present study demostrated the M-protein to interfere with fibrin monomer polymerization. The disease had responded to MIP therapy very well, and the clot retraction became to normal in accordance with the disappearance of the M-protein.
