Abstract
Two cases of plasma cell leukemia (PCL) are reported. The first case was 52-year-old male (Case K. K.). He was admitted to Toho University Hospital on April 10, 1980, because of abnormal peripheral blood picture and anemia. Hepatosplenomegaly, mild anemia, thrombocytopenia and petechiae were present. The WBC count was 10,400/cmm, with 66% of plasma cells. Some of plasma cells showed lymphoid configuration, but possessed surface IgDλ. Serum IgD level was as high as 1,300 mg/dl and Bence Jones proteinuria was present. The diagnosis of IgD PCL was made, and he received the intensive combination chemotherapy of ADM, VCR, CPM and PSL. Notable improvement was obtained after the chemotherapy, but severe hypogammaglobulinemia developed gradually. He died of sepsis at the 7th month from the time of diagnosis.
The second case was 76-year-old male (Case A. I.) with IgG multiple myeloma, who had been successfully treated with cyclophosphamide and β-methason. As his conditions deteriorated at the terminal stage of myeloma, many plasma cells (80.5%) appeared in the peripheral blood. He was diagnosed as PCL and died of cardiac failure. At autopsy, diffuse and extensive infiltrations of plasma cells into multiple organs were detected. It was suggested that PCL should be treated with intensive combination chemotherapy.
