Abstract
A 62-year-old male with adult T-cel lymphoma of pleomorphic type and eosinophilia was reported. He was admitted to the Otolaryngology Department because of the tosillar malignant tumor on March 13, 1979. After the disappearance of the tumor by radiation therapy he was transferred to the Department of Internal Medicine because of abdominal distension and severe diarrhea in Aug. 1979.
On admission physical examination showed generalized lymphadenopathy, hepatosplenomegaly and ascites. Laboratory findings included WBC of 26,700/mm3 with 50% of eosinophils and 8% of lymphocytes, and a bone marrow aspirate showed eosinophilia with no atypism. Diagnosis of malignant lymphoma of diffuse pleomorphic type was made by an inguinal lymph node biopsy. The tumor cells obtained from the node formed rosette with sheep red cells, but no surface immunoglobulin nor EAC rosette formation were detected.
By combination chemotherapy (COPP) eosinophilia disappeared rapidly with improvement of other symptoms within a month. Interstitial pneumonia occurred on Oct. 3, 1979. In spite of a transient effect by trimethoprim-sulfamethoxazole he died of respiratory disturbances on Dec. 18, 1979.
On autopsy mild invasion of lymphoma of diffuse pleomorphic type was detected into the lymph nodes of retroperitoneum and liver. The cause of death was attributed to the interstitial pneumonia. In this paper the authors tried to discuss the relationship of T-cell lymphoma of adult pleomorphic type to the eoninophilia with the review of the literature.
