Abstract
A 50-year-old woman with atypical acute myeloblastic leukemia after 131I therapy for hyperthyroidism is described. She had been treated with 12 mCi of 131I because of hyperthyroidism three years before admission to the hospital on February 12, 1975. On admission, hematologic examination showed marked anemia and a white cell count of 1,300 with 1% myeloblasts and 34% monocytes. Peroxidase reaction of myeloblasts was negative.
Bone marrow aspirate revealed 16.8% myeloblasts and 9.0% promyelocytes. Platelet count was normal. Blood transfusion, prednisolone and 6 MP were effective to her.
But monocytosis and mild myeloblastosis continued for 20 months after admission. Following the atypical leukemic stage, marked myeloblastosis abruptly developed one month prior to death. She died on September 17, 1976.
