Abstract
The second case of thrombotic thrombocytopenic purpura (TTP) treated successfully by warfarin, dipyridamole and aspirin is reported. A 38 years old housewife with the pentad of hemolytic anemia, thrombocytopenic purpura, fever, renal dysfunction and complicated neurologic symptoms did not respond to dipyridamol and aspirin initially. However, when the value of thrombotest decreased less than 20% after the administration of warfarin and prednisolon, the improvement of her various symptoms and laboratory findings was observed.
The level of circulating immune complex had been always within normal range in the clinical course.
The effectiveness of the oral anti-coaqulant, warfarin to TTP combined with antiplatelet agents and the evaluation of other therapies including exchange transfusion, antiplatelet agents, heparin and corticosteroid were discussed on our cases refering with literatures.
