Abstract
Twenty two cases of hypoplastic leukemia among atypical leukemia were diagnosed by the findings of bone marrow tissue sections at the first examination of patient's visit of the clinic, and the following results were obtained from clinical findings and the course of treatment.
(1) The average fatty area rate of biopsied tissue sections taken from 22 hematologically normal persons by aspiration-biopsy instrument (Miyasaka's needle) was 52.2±9.8%. Therefore, over 63% fatty area rate of biopsied tissues were determined as hypoplastic. The average fatty area rate of biopsied bone marrow in 8 cases on hypoplastic leukemia was 72.1±4.2%.
(2) The incidence of hypoplastic leukemia was 22 cases (4.2%) among 517 cases of acute leukemia, of which 12 cases (54.5%) were over 60 years old.
(3) The blast of peripheral blood was 2.7% (range 1 to 8%), and the sum of the blasts and promyelocytes of the bone marrow on 22 cases showed 21.7% (range 4.6 to 37%).
(4) The nests of immature cells in the biopsied tissue were detected in almost cases. So, the examination of biopsy is thought to be necessary for the diagnosis of hypoplastic leukemia.
(5) As for the treatment of hypoplastic leukemia, intermittent administration of multi-chemotherapeutics, such as 4 agents with 1/3 to 1/2 doses, was suggested to be necessary when the sum of the blasts and promyelocytes was over 30%. The two cases treated with interferon showed extension of the blood transfusion period and the temporary erythrocytosis.
