1983 Volume 24 Issue 3 Pages 263-270
We experienced a concurrence of adult T-cell lymphoma in father and daughter.
A 34 year-old woman born in Ehime Prefecture developed inguinal lymphadenopathy in March, 1981. The diagnosis of diffuse lymphoma (plemorphic type) was made by the biopsies which were done at her right inguinal lymph node in April, and at right axillary lymph node in May, 1981. Lymphoma cells had T-lymphocyte surface markers [T 101 (+), OKT3 (+), OKT4 (+), sIg (-), TdT (-)], but ERFC was negative in lymphnode suspension. In spite of strong chemotherapy, radiotherapy and immunotherapy, she died in January, 1982.
Her father born in Ehime Prefecture was 68 years old. In April, 1981, he developed cervical lymphadenopathy and was died in October, 1981. Right cervical lymph node biopsy revealed diffuse lymphoma (medium-sized cell type) which was highly suspected to be T-cell lymphoma. His clinical findings and clinical course supported the diagnosis of adult T-cell lymphoma.
Anti ATLA antibody titer was positive in her (×40), her husband (×20) and her mother (×40). Her father was not examined anti ATLA antibody, and her other siblings and her children were negative (<×10).
It is a interesting case for studying the etiology of adult T-cell lymphoma.
