1983 Volume 24 Issue 3 Pages 271-275
Transient pure red cell aplasia was observed in a 38 years old woman after one month administration of α-methyl-DOPA (Aldomet 375 mg/day). Discontinuation of Aldoment brought about recovery of normal erythropoiesis. In this patient, patient's serum did not inhibit the normal erythropoiesis, but patient's peripheral mononuclear cells had a suppressor activity for BFU-E of normal human peripheral blood. It was assumed that in this patient the circulating peripheral mononuclear cells play a pathognomonic role for transient pure red cell aplasia by their suppressing activity on the proliferation of erythroid precurser (BFU-E), and Aldomet may contribute to the presence of such suppressive peripheral mononuclear cells.
