1985 Volume 26 Issue 4 Pages 527-531
A 66 year-old man was admitted because of generalized lymphadenopathy.
A diagnosis of immunoblastic lymphadenopathy was established from the characteristic histology of cervical lymph node with increased ESR and γ-globulin fraction.
Therapy with prednisolone and cyclophosphamide improved his physical state in some degree; however the patient died from severe respiratory tract infection three months after admission.
A high titer of anti-viral capsid antibody-IgG for EB virus was noted to persist throughout the clinical couse.
In addition, EB nuclear antigen antibody changed to positive while stay in hospital.
Electronmicroscopic examination of the lymph node revealed some particles with high electron density.
Although the particles are not clasified as the products of EB virus, they are suggestive that the cells in the lymph node were infected by EB virus.
From these findings, it was suggested that immunoblastic lymphadenopathy in our patient was caused by the infection of EB virus.
