1985 Volume 26 Issue 9 Pages 1458-1462
The therapeutic effect of malignant lymphomas (MLs) of aged patients (70 year-old over) were studied. The studied cases were consisted of eighteen, all non-Hodgkin's, nine T cell MLs, and nine B cell MLs, and in stage III and IV. T-cell MLs were treated with various doses of BACOP: two with 2/3 dosage, four with 1/2 and three with 1/3. Their complete remission rate was 56% as a whole and the median survival was four months. All patients with 2/3 dosage treatment represented severe myelosuppression and died from sepsis. In other case of T cell MLs, the degree of myelosuppression was mild but for two cases, the one with hypoplastic marrow from the beginning and the other with low level of creatinine clearance. Other severe adverse reactions were ileus and SIADH. Nine B cell MLs were treated with various regimens mainly consisting of cyclophosphamide, vincristine and predonisolone. Complete remission rate of these cases was 44% and median survival was 18 months, which were lower and shorter than the values of younger patients. They did not have any severe adverse reaction.
