1985 Volume 26 Issue 9 Pages 1463-1466
Clinical, hematologic, and immunologic studies were performed on five children with defective monocyte chemotaxis. The five patients were among about 100 children with a history of recurrent infections who were studied for monocyte chemotaxis in Shinshu University Hospital, and included siblings (sister and brother) with primary monocyte dysfunction, one with Chédiak-Higashi syndrome and two with hyper-IgE syndrome. In all of the patients, candidiasis was recurrent and delayed type hypersensitivity was absent. These results indicated that these clinical features were characteristic in patients with defective monocyte chemotaxis.
