Abstract
A 25-year-old housewife was transferred to our hematologic department with severe genital hemorrhage and bleeding of gums, 5th day after delivery. Physical examination revealed anemia. The white blood cell count was 1,470/cmm and the platelet count was 29,000/cmm. Atypical promyelocytes were 63% of peripheral WBC and 82% of bone marrow cells. Normal ESR, hypofibrinogenemia and a high level of FDP were observed.
The therapy was started under a diagnosis of acute promyelocytic leukemia, but she died, 75 days after delivery. Autopsy findings revealed partial proliferation of leukemic cells in the bone marrow. Marked bleeding in several organs and fibrin thrombi in the glomerular capillaries were noted.
To date the child is healthy.
Including our case, 20 cases of pregnancy with acute promyelocytic leukemia were reported in Japan since 1969. Two cases were not received chemotherapy during pregnancy. Hematologic examinations showed the findings of leukemia in none of infants.
