Abstract
A 56-year-old female, who had been diagnosed as ITP and treated with prednisolone for 3 years, was recently complicated with autoimmune hemolytic anemia and was thought to be Evans' Syndrome.
Usual dose of prednisolone was orally given at the first time and anemia was markedly improved except Thrombocytopenia.
Therefore pulse therapy (Methylprednisolone 1000 mg 3 days iv) was carried out.
As soon as pulse therapy was done, not only anemia but also thrombocytopenia was markedly improved except decrease of serum immunoglobulin (especialy IgG).
The remission continued for 6 months. But pulse therapy had to be done again because of Thrombocytopenia.
Although the recovery of the platelet was slightly delayed, the effect of pulse therapy remained stable for 5 months.
From these results it was suggested that one shot pulse therapy was markedly effective remission induction of Evans' syndrome.
