A Case of Burkitt's type Lymphoma Diagnosed by Cell Surface Markers

Abstract

Burkitt's Lymphoma was first reported as primary extra lymphatic tumor involving maxillary bones of African children. It has classified Burkitt's lymphoma and Burkitt's type lymphoma by serological antibodies titer of EB virus. In epidemic regions of Burkitt's lymphoma serologic evidences of EB virus infection has been documented repeatedly.
About 50 cases included Burkitt's lymphoma and Burkitt's type lymphoma have been reported in Japan.
We report a case of Burkitt's type lymphoma in 11 year-old boy, who was admitted because of right palatine tonsillar tumor. Histological examination of the tumor showed small non cleaved cell type malignant lymphoma with scattered the starry-sky appearance. Studies of cell surface markers revealed that tumor cells were B₁⁺ B₂^- SmIgM⁺ J₅⁺. EB virus antibodies titer was low. Final diagnosis was Burkitt's type lymphoma.
Since the clinical stage was A (by ziegler's classification), he was treated by six courses of cylophosphamide 40 mg/kg alone.
He achieved complete remission lasting for 41 weeks at this report.