1988 Volume 29 Issue 11 Pages 2105-2110
A 16-year-old male was hospitalized because of submandibular lymphonode swelling and general fatigue. He was diagnosed as acute lymphocytic leukemia (ALL) which was morphologically characterized by L2 (FAB classification) and immunologically determined by T-cell type. A combination chemotherapy was carried out and successfully induced complete remission. 11 months later, he died from a intracranial bleeding with hematological relapse.
In cytogenetic examination of pathological cells and normal lymphocytes in complete remission, constitutional chromosome anomalies of 47, XYY was observed in all of 20 metaphases examined respectively.
His mother died of acute promyelocytic leukemia (APL-M3) 3-years before his admission in our hospital.
These cases are suspected as familial leukemia, and this is the first case report of lymphocytic leukemia in XYY male with familial occurrence of leukemia.
