同種骨髄移植を施行したBurkitt's Lymphoma (Stage IV)の3例

宮村 耕一; 竹山 邦彦; 松下 正; 木村 之彦; 南 三郎; 吉田 潤; 松山 孝治; 小寺 良尚; 山内 辰也; 平岩 明和; 伊藤 貴彦; 北折 健次郎; 森島 泰雄; 上田 一博

doi:10.11406/rinketsu.29.149

Allogeneic Bone Marrow Transplantation for Burkitt's Lymphoma (Stage IV)

Kohichi MIYAMURA, Kunihiko TAKEYAMA, Tadashi MATSUSHITA, Masahiko KIMURA, Saburoh MINAMI, Jun YOSHIDA, Kohji MATSUYAMA, Yoshihisa KODERA, Tatsuya YAMAUCHI, Akikazu HIRAIWA, Takahiko ITOH, Kenjiroh KITAORI, Yasuo MORISHIMA, Kazuhiro UEDA

Author information

Kohichi MIYAMURA
Department of Internal Medicine, The Japanese Red Cross Nagoya First Hospital
Kunihiko TAKEYAMA
Department of Internal Medicine, The Japanese Red Cross Nagoya First Hospital
Tadashi MATSUSHITA
Department of Internal Medicine, The Japanese Red Cross Nagoya First Hospital
Masahiko KIMURA
Department of Internal Medicine, The Japanese Red Cross Nagoya First Hospital
Saburoh MINAMI
Department of Internal Medicine, The Japanese Red Cross Nagoya First Hospital
Jun YOSHIDA
Division of Hematology/Oncology, Children's Medical Center, The Japanese Red Cross Nagoya First Hospital
Kohji MATSUYAMA
Division of Hematology/Oncology, Children's Medical Center, The Japanese Red Cross Nagoya First Hospital
Yoshihisa KODERA
Department of Internal Medicine, The Japanese Red Cross Nagoya First Hospital
Tatsuya YAMAUCHI
Department of Internal Medicine, Nagoya University Branch Hospital
Akikazu HIRAIWA
Department of Internal Medicine, Nagoya University Branch Hospital
Takahiko ITOH
First Department of Internal Medicine, Nagoya University School of Medicine
Kenjiroh KITAORI
First Department of Internal Medicine, Nagoya University School of Medicine
Yasuo MORISHIMA
First Department of Internal Medicine, Nagoya University School of Medicine
Kazuhiro UEDA
Department of Pediatrics, Hiroshima University School of Medicine

Keywords: malignant lymphoma, Burkitt's lymphoma, bone marrow transplantation

JOURNAL RESTRICTED ACCESS

1988 Volume 29 Issue 2 Pages 149-155

DOI https://doi.org/10.11406/rinketsu.29.149

Details

Abstract

The prognosis of patients with Burkitt's lymphoma in Japan is usually poor, compared with that of the American and European cases, and the median survival period of the patients with “Stage IV” has been reported to be 2.3 months. Three cases of Burkitt's lymphoma (Stage IV) were treated with allogeneic bone marrow transplantation following a high dose chemoradiotherapy during their remission (2 in the 1st and 1 in the 2nd remission).
All were conditioned with cyclophosphamide (60 mg/kg/day) in day -5 and -4 and total body irradiation (10-12Gy) in day-2 and -1 and one received additional cytosine arabinoside and cerebrospinal and local irradiation. Two were grafted from HLA compatible siblings and another was from a DR-incompatible sibling. Engraftment was confirmed in all cases. One patient transplanted during 2nd CR died of relapse on the 160th day after the BMT. Remaining two cases, transplanted in their first remission, survived for more than 12 and 60 mos after the BMT without a recurrence of the disease. Allogeneic bone marrow transplantation for the treatment of Burkitt's lymphoma (Stage IV) might be a curative procedure, if it is performed in the 1st CR.

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