Abstract
1. Among the 77 cases of hemophiliacs (61 hemophilia A patients and 16 hemophilia B patients), three types of HIV-I marker, for HIV-I antigen (p 24) and HIV-I antibody (gp 41, p 24), were examined. Periodical check was conducted from 1980 thru to 1982 on the 11 cases (3 ARC and 8 AC cases) of them to observe relation among HIV-I marker, clinical symptoms and immunity (CD4/CD8 ratio).
2. HIV-I antigen was found in 2 cases of the 77, each later diagnosis as ARC hemophilia B.
3. In the check on serum before seroconversion, 8 cases of asymptomatic carrier have shown no positive reaction to HIV-I antigen.
4. Of the 27 cases positive to HIV-I antibody, all the 27 cases proved to have envelope protein gp41 but the check for core protein p 24 resulted its absence in 3 cases of them.
5. Of the ARC cases, 1 case showed decrease in HIV-I antigen and recovery of HIV-I antibody (p 24) when the patient condition turned for the better. Whereas, ARC case in which symptoms were critically developed of HIV-I antigen and looses of HIV-I antibody (p 24).
6. Periodic observation on HIV-I infected persons for the change of quantity of HIV-I antigen (p 24) and HIV-I antibody (gp 41 and p 24) seems to be useful to judge the time of infection and prognosis.
