Erythropoietic Effect of Androgen on Anemia Associated with Klinefelter's Syndrome

Abstract

A patient with Klinefelter's syndrome complicated with anemia was reported.
The presence of an ineffective erythropoiesis was suggested from the blood and bone marrow findings. The HbF level was markedly elevated. Following the androgen therapy, he was recovered from anemia and the HbF level was reduced.
These results may support the following hypotheses: 1) The condition of an arrested cell cycle in the erythroblasts (ineffective erythropoiesis) causes an elevation of the HbF level. 2) Androgen administration is capable of improving on ineffective erythropoiesis and of reducing the HbF level.