Rinsho Ketsueki
Online ISSN : 1882-0824
Print ISSN : 0485-1439
ISSN-L : 0485-1439
Treatment of Acute Lymphoblastic Leukemia in Adults by the Modified Protocol of L-10M (Sloan-Kettering)
Hiroaki NONAKAKazutaka KURIYAMATakao YANAGISAKOTomoko SATOHYasushi MIYAZAKIKazuhiro NAGAISeiji TOKUNAGAKen MURATATakahiro MAEDASunao ATOGAMITakaharu ITOYAMAKunihiro TSUKASAKITomoko KOHNOIppei SASAGAWAYukiyoshi MORIUCHIHisashi SOHDAHideo NAKAMURAKazuhiro TORIYASaburo MOMITATohru JUBASHITatsuhiko AMAGASAKITatsuki MATSUOYoshiharu YOSHIDATatsuhiko AMENOMORIYasuaki YAMADAYukinobu OYAKAWAShuichi IKEDANaoki SADAMORIMasao TOMONAGAMichito ICHIMARUShimeru KAMIHIRAMiyuki KUSANOMasuko TAGAWA
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1990 Volume 31 Issue 6 Pages 807-812

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Abstract
We have treated 20 adult patients with acute lymphoblastic leukemia (ALL) and 2 patients with lymphoblastic lymphoma with a protocol modified from L-10M of the Memorial Sloan Kettering Cancer Center. Eighteen patients (81.8%) entered complete remission (CR). Eight of them eventually relapsed (only 1 patient had a meningeal relapse) and died. Median CR duration was 19 months (median overall follow-up of 35 months and 50% remission duration was not yet determined. Median overall survival was 19 months. Three patients died of sepsis during remission induction, but all of other deaths were due to resistant or relapsed leukemia. The four patients who completed 3.5 year's modified L-10M protocol were free from relapse for 6-11 months (mean 8.7). Although further follow-up is necessary, we suggest that modified L-10M protocol is effective for adult ALL and long-term survival may be available.
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© 1990 The Japanese Society of Hematology
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