婦人科開腹術後の肥厚性瘢痕の発生·増悪に対するトラニラストの予防的効果—多施設共同研究

後藤 栄; 高倉 賢二; 廣瀬 雅哉; 木村 俊雄; 竹林 浩一; 秋山 稔; 中西 桂子; 布留川 浩之; 木村 文則; 野田 洋一; 山本 嘉昭; 千葉 隆史; 田中 京子; 藤原 睦子; 金 美娘; 尾上 敏子; 三野 直純; 喜多 伸幸; 山本 依志子; 和久田 晃司; 藤本 喜展; 田村 和也; 天崎 寿夫; 中山 茂樹; 林 嘉彦; 井上 貴至; 中村 恵美; 石川 弘伸; 山出 一郎; 石河 顕子; 藤谷 真弓; 濱田 浩明

doi:10.11437/sanpunosinpo.53.197

Original

Preventive effect of tranilast on keloid and hypertrophic scar formation after gynecological surgery Multicenter study

Sakae GOTO, Kenji TAKAKURA, Masaya HIROSE, Toshio KIMURA, Koichi TAKEBAYASHI, Minoru AKIYAMA, Keiko NAKANISHI, Hiroyuki FURUKAWA, Fuminori KIMURA, Yoichi NODA, Yoshiaki YAMAMOTO, Takashi CHIBA, Kyoko TANAKA, Mutsuko FUJIWARA, Miran KIN, Toshiko ONOE, Naozumi MITSUNO, Nobuyuki KITA, Yoshiko YAMAMOTO, Koji WAKUDA, Yoshinori FUJIMOTO, Kazuya TAMURA, Toshio TENZAKI, Shigeki NAKAYAMA, Yoshiko HAYASHI, Takashi INOUE, Emi NAKAMURA, Hironobu ISHIKAWA, Ichiro YAMADE, Akiko ISHIKO, Mayumi FUJITANI, Hiroaki HAMADA

Author information

Sakae GOTO
Department of Obstetrics and Gynecology, Shiga University of Medical Science
Kenji TAKAKURA
Department of Obstetrics and Gynecology, Shiga University of Medical Science
Masaya HIROSE
Department of Obstetrics and Gynecology, Shiga University of Medical Science
Toshio KIMURA
Department of Obstetrics and Gynecology, Shiga University of Medical Science
Koichi TAKEBAYASHI
Department of Obstetrics and Gynecology, Shiga University of Medical Science
Minoru AKIYAMA
Department of Obstetrics and Gynecology, Shiga University of Medical Science
Keiko NAKANISHI
Department of Obstetrics and Gynecology, Shiga University of Medical Science
Hiroyuki FURUKAWA
Department of Obstetrics and Gynecology, Shiga University of Medical Science
Fuminori KIMURA
Department of Obstetrics and Gynecology, Shiga University of Medical Science
Yoichi NODA
Department of Obstetrics and Gynecology, Shiga University of Medical Science
Yoshiaki YAMAMOTO
Takeda General Hospital
Takashi CHIBA
Takeda General Hospital
Kyoko TANAKA
Takeda General Hospital
Mutsuko FUJIWARA
Fujimoto Hospital
Miran KIN
Fujimoto Hospital
Toshiko ONOE
Kyoto Senbai Hospital
Naozumi MITSUNO
Kusatsu General Hospital
Nobuyuki KITA
Social Insurance Shiga Hospital
Yoshiko YAMAMOTO
Social Insurance Shiga Hospital
Koji WAKUDA
Shingu Civil Hospital
Yoshinori FUJIMOTO
Shingu Civil Hospital
Kazuya TAMURA
Shingu Civil Hospital
Toshio TENZAKI
Uji Tokushukai Hospital
Shigeki NAKAYAMA
Nakayama Clinic
Yoshiko HAYASHI
Hikone Central Hospital
Takashi INOUE
Hino Memorial Hospital
Emi NAKAMURA
Hino Memorial Hospital
Hironobu ISHIKAWA
Minakuchi Civil Hospital
Ichiro YAMADE
Yao Tokushukai General Hospital
Akiko ISHIKO
Yao Tokushukai General Hospital
Mayumi FUJITANI
Yao Tokushukai General Hospital
Hiroaki HAMADA
Yasu Hospital

Keywords: tranilast, keloid, hypertrophic scar

JOURNAL RESTRICTED ACCESS

2001 Volume 53 Issue 3 Pages 197-202

DOI https://doi.org/10.11437/sanpunosinpo.53.197

Details

Abstract

The purpose of the study was to investigate a preventive effect of tranilast on hypertrophic scar formation after gynecological surgery. Patients who has gynecological surgery from June 1998 to May 1999 were assigned to two groups: a tranilast-treated group and a group not treated with tranilast (a non-treatment group). Tranilast was initiated on the seventh day after surgery, and the period of treatment was 4 months. Subjective symptoms and objective signs of 38 tranilast-treated patients and 20 non-treatment patients were analyzed. Objective signs in a tranilast-treated group were significantly superior to those in the non-treatment group. The results of the present study showed that tranilast is useful in preventing hypertrophic scar formation after gynecological surgery.

Corresponding author

Register with J-STAGE for free!