人原発性肝癌と胎児性α-globulin
(第1報)臨床的研究を中心として
1971 年 15 巻 4 号 p. 261-265
詳細
1971 年 15 巻 4 号 p. 261-265
Sera of 406 patients with various diseases and 5, 998 healthy adults were tested for the fetal α-globulin (αf-globulin) by single radial immunodiffusion test and Ouchterlony's test using a specific horse antiserum.
αf-Globulin was detected specifically in patients with primary liver cancer with only one exception. Sera of 31 among 40 patients with histologically confirmed hepatoma gave positive tests, but sera of 6 patients with histologically confirmed cholangioma gave negative tests. Serum αf-globulin levels were determined by single radial immunodiffusion test using a purified αf-globulin as standard.
The determined values showed a very wide distribution from 375mg/dl to 1mg/dl, the limit of the sensitivity.
Quantitative study showed that αf-globulin test was useful not only for diagnostic purpose but also for judging the response to treatments or for monitoring the progress of the disease.
