抄録
To clarify the roles of immunological reaction and virus as to prolongation or chronic process of viral hepatitis, clinical features were reviewed and analysed.
Abnormal response of hepatic mesenchyma, as suggested by positive TTT and ZTT and hyper-γ-globulinemia, were indicated to have a strong influence on clinical course of hepatitis. Continued fluctuating phenomenon of serum transaminase levels suggesting persistent hepatic cellular degeneration and necrotic change was found to be an influential factor on prolongation or chronicity. Serum transaminase fluctuation was diminished or turned to normal when this abnormal mesenchymal response became persistent. Clinical and pathological difference of “persistent hepatitis” (“persistierende hepatitis”) of Smetana and Wildhirt and hepatic diseases as cholestatic hepatitis were also discussed. Constantly positive HBs, serum colloidal reaction, hyper-γ-globulinemia and RA test were also studied and discussed.
