一方の種のミトコンドリアDNAが脱落したマウス-ラットハイブリット細胞におけるミトコンドリア局在型酵素の発現
1986 年 30 巻 6 号 p. 437-441
詳細
1986 年 30 巻 6 号 p. 437-441
Expression of mitochondrial superoxide dismutase (mtSOD) was examined using mouse-rat hybrid clones, H2-8 and H5, that had lost either parental mtDNA species.
Restriction analysis showed that H2-8 contained rat mtDNA only and H5 contained mouse mtDNA only. Zymogram of mtSOD in these hybrid clones suggested that only rat mtSOD was expressed in H2-8 mitochondria, whereas both rat and mouse mtSOD were expressed in H5 mitochondria that contained mouse mitochondrial genome only.
Thus, rat mtSOD can be incorporated into mitochondria with mouse mitochondria genome.
