健常人における血清コリンエステラーゼC₅変異の推定頻度

抄録

We examined the distribution of C₅ variant among 310 sera from healthy individuals. The frequency of the C₅ variant was 2.3% and was similar to that in all Negro and Korea samples. The ChE activity for the C₅ variant among healthy individuals was from 458 to 710U/l. Three cases of them showed lower ChE activity than 573U/l (mean+1SD of C₅-individuals). These results suggest that we must try to detect the C₅ variant not only in high ChE activity sera but also in low ChE activity sera. We caluculated the ratio of ChE activity to Alb (ChE/Alb) and then tried to detect the existence of C₅ variant among the samples. However, it was difficult to detect the existence of the C₅ variant completely. At present, our simple ChE activity staining method following PAG electrophoresis is most useful for detecting the C₅ variant.