1993 Volume 37 Issue 1 Pages 19-23
Serum amyloid A (SAA) protein is a sensitive and rapid acute phase reactant and its meaurement is gaining wide spread acceptance for the monitoring of inflammatry diseases and assessing the prognosis in secondary amyloidosis.
We set up a latex agglutination nephelometric immunoassay system for the quantitation of SAA in human serum. SAA-enriched HDL (high density lipoprotein) which SAA content was determined electrophoretically, was used as assay standard. The values determined by this method related with enzyme immunoassay using the same antibody and standard. The mean value of SAA in normal serum (n=100) was 1.1μg/ml and ranging 0.48-4.8μg/ml (mean±2 SD).
The log SAA vs log CRP ratio showed essentialy the same values in patients with rheumatoid arthritis, acute myocardial infarction, bacterial pneumonia, lung cancer, gastrointestinal cancer, surgical operation, while significantly higher values were obtained in patients with rubellosis, cytomegalo virus infection and kidney allograft rejection. This rapid measurement method of SAA may fit application for the routine use.
