抄録
An increase in diseases due to arteriosclerosis, together with malignant tumor, has been remarkable in recent years, and studies on arteriosclerosis have become active. Thus it has been clarified that the disease is closely related to abnormal lipometabolism in the human body. As a series of clinobiochemical studies on serum proteins and compound proteins which have been carried out in this clinic for several years, the present author studied abnormal lipometabolism in arteriosclerosiss from a viewpoint of alternations of findings in the serum of hypertensive patients and the serum of cholesterol-fed rabbits. In this connection, observation was made, with the following conclusions, on alternations of findings in proteins and glycoprotein as well as yearly alternations of findings in serum proteins and glycoprotein.
1. In rabbits with hypercholesteremia, the concentration of blood cholesterol showed no correlation to the β-lipoprotein fraction, and there was an increase in lipoprotein of a very low specific gravny.
2. A slight decrease in the serum total protein, a decrease in albumin and an increase in the globulin fraction took place in essential hypertension, regardless of whether or not it was complicated by arteriosclerosis.
3. The total cholesterol level in arteriosclerosis, hypertension and old age was high in this order. The level is useful for determining whether or not essential hypertension is complicated by arteriosclerosis. In a group of diseases, the ester cholesterol/total cholesterol ratio exhibited a decrease. In this case there was a correlation between the total cholesterol level and the β-lipoprotein fraction.
4. In old age, the γ-lipoprotein fraction showed an increase, while the α- and β-lipoprotein fractions exhibited an increase. In both groups a decrease in the α-lipoprotein fraction took place to almost the same extent. The maximal level of the β-lipoprotein fraction occurred in arteriosclerosis. The γ-lipoprotein/α-lipoprotein ratio and the β-lipoprotein/α-lipoprotein ratio showed a striking increase in old age and arteriosclerosis, respectively. The β+γ-lipoprotein/α-lipoprotein ratios for both were 3.2 and 3.1; almost no difference in the ratio was observed.
5. An increase in the α2-glycoprotein fraction was significant in arteriosclerosis; the P. B. P. showed a high level in cerebrosclerosis. The P. B. P. level and the α2-glycoprotein fraction for hypertensive patients, slightly hypertensive patients and patients with arteriosclerosis gave high values in the reverse order. There was a slightly significant correlation between both.
