Abstract
Cholesterol had been used for a long time as the technique for suppressing the leakage of inclusions on liposome. The effect of leakage suppression on inclusions of cholesterol above the phase transition temperature was known. However, there has been a problem that the leakage of the inclusions below the phase transition temperature cannot be fully suppressed. Therefore, we examined various combined lipids to find an ingredient to suppress the leakage of the inclusions on liposome below the phase transition temperature. As a result, we found that 1, 2-alcanediols (carbon chain length C8-10) suppress the leakage from liposome compared with the cholesterol. The effect of 1, 2-decanediol is especially high because 1, 2-decanediol suppresses the fluidity of the hydrophilic and hydrophobic groups of the membrane of liposome below 45°C . From these results, we found that leakage of the inclusions are suppressed in the temperature range below the phase transition temperature by adding 1, 2-decanediol. It wasconfirmed that liposome which consists of the above ingredient possesses a controlled-release effect at skin temperature (33°C).
