Abstract
Recently, there has been a great demand in the cosmetic industry for development of a new chemical which shows preservative effects. In this study, to meet the industrial demand, 4 kinds of alkyl dimethylol alkanates (ADMA) were synthesized and were evaluated for their antimicrobial activities. In addition, the antimicrobial action mechanisms of ADMA were discussed with their interfacial parameters in water solution. In the results, hexyl dimethylol propionate gave a superior antimicrobial effect among ADMAs. In addition, the surface tension measurement in water solution suggested that the ADMA with higher antimicrobial ability showed a tendency to be absorbed interfacially and to be well-packed on the interface. Antimicrobial parameters of ADMA, which were calculated from the results of antimicrobial tests, demonstrated positive correlations with interfacial parameters, especially cmc/C20 and Γcmc. Therefore, it was concluded that the interfacial parameters could be a screening parameter for developing antimicrobial components.
