3-O-Glyceryl Ascorbate Suppresses Hypoformation of Elastic Fiber Induced by UVA, Blue Light and Near-Infrared Light

Abstract

Sunlight includes ultraviolet (UV) light, visible light and near-infrared (NIR) light. Recent studies have shown that not only UVA but also blue light (BL) and NIR accelerate the photoaging symptoms of skin associated with fiber depletion of collagen and elastin in the dermis. In this study, we examined the influence of UVA, BL and NIR on the reconstruction of elastic fibers by measuring mRNA expression of elastic fiber related proteins and fluorescence immunostaining of Fibrillin-1. UVA, BL and NIR increased intracellular ROS of cultured human fibroblasts, and showed suppression of construction and enhancement of decomposition in elastic fiber. On the other hand, 3-O-glyceryl ascorbate (VC-3G) which is an ascorbic acid derivative and possesses antioxidative property, suppressed the elevation of intracellular ROS and restored the mRNA expression levels of elastic fiber related proteins and incomplete construction of elastic fiber induced by UVA, BL and NIR. Taken together, we conclude that VC-3G is an effective derivative of ascorbic acid to prevent depletion of elastic fibers initiated by solar light.