Reducing Effects of Protain Denaturing Potency of Ionic and Amphoteric Surfactants by Introducing Oxyethylene Residue in their Structures

Abstract

In order to widely investigate the reducing effects of protein denaturing potency of ionic and amphoteric surfactants by introducing oxyethylene residue in their structures, we synthesized 15 surfactants of five families, so called, [F-1] Dodecyl sulfate and dodecyl poly (ave. 2 and 4) oxyethylene sulfates, [F-2] N-dodecyl betain and N-dodecyl poly (ave. 2 and 4) oxyethylene betains, [F-3] N-tetradecyl betain and N-tetradecyl poly (avc. 2 and 4) oxyethylene betains [F-4] N-dodecyl-N, N-dimethyl amine oxide and N-dodecyl poly (ave. 2 and 4) oxyethylene-N, N-dimethyl amine oxides, and [F-5] N-dodecyl-N, N, N-trimethyl ammonium chloride and N-dodecyl poly (ave. 2 and 4) oxyethylene-N, N, N-trimethyl ammonium chlorides.
The albumin protein denaturing potencies of these surfactants were measured on various concentrations.
In above five families, especially in the case of [F-2], [F-3] and [F-4] we found that introducing oxyethylene residue in their structures gave remarkable reducing effects of albumine denaturing potencies.