Dissolution and Anti-crystallization Mechanism of Monoglyceride in Ethanol Solution

Abstract

The present study relates to the effects of Solubitan laurate (SL-10) and Amphoteric methacrylic copolymer (YUKAFORMER) on dissolution and crystallization of Glyceryl monopentadecanote (PDG) in ethanol.
Because of the poor solubility, PDG tends to precipitate from ethanol at low temperature (below 10°C). To improve the solution stability, it was found that the addition of SL-10 and YUKAFORMER inhibit the precipitation of PDG from the ethanol solution even at -10°C-+25°C.
The following mechanism of the stabilization has been assessed by using DSC, Dynamic light scattering, analyzing the precipitates.
(1) SL-10 and YUKAFORMER formed molecular assembly with PDG to prevent the formation and growth of PDG crystal.
(2) YUKAFORMER having a lot of hydrophiric groups in the molecule changed the hydrophobic of the molecular assembly to increase the solubility at low temperature in ethanol.
The observation is supported by the Molecular Mechanics calculations.