抗菌剤ヒバ油の安全性試験

1. 皮膚感作性試験

抄録

An antimicrobial agent, hiba oil, was examined for contact allergenicity in a modified guinea pig maximization test. Hiba oil produced weak contact allergenicity by intradermal injection dose at ≥5, 000ppm and challenge doses at 5, 000ppm. Even at the highest intradermal dose of hiba oil (50, 000ppm), only half of the animals showed a positive skin reaction to the challenge patch of hiba oil at 5, 000ppm. Two antimicrobial components of hiba oil, hinokitiol and carvacrol, were not the critical substances of allergenicity, as these chemicals failed to cause positive skin reaction in a cross-sensitization test.