2014 Volume 57 Issue 4 Pages 333-342
Purpose: A new dentin desensitizer,“Nanoseal” , can be easily applied without rubbing to produce a layer of nano-particles on dentin surfaces which occlude dentinal tubules and suppress hypersensitivity (Hys). The purpose of this study was to confirm the occlusion of dentinal tubules by using FE-SEM and to evaluate the clinical desensitizing ability of Nanoseal. A clinical evaluation was conducted one week after application by the criteria of not only sensitivity to cold air and scrubbing stimulation but also Hys symptoms in daily life.
Materials and methods: Nanoseal was applied to 101 patients with Hys and rinsed off. Pain symptoms were evaluated before and after application. The effectiveness of desensitization was examined at the next appointment (after one week) by sensitivity to cold air, scrubbing stimulation and Hys symptoms during one week of daily life. An overall rating of effectiveness was determined by the changes in Present Pain Intensity (PPI) with a 6-grade scale in conjunction with the changes in Visual Analogue Scale (VAS) value.
Results:
A. Dentinal tubule occlusion
Nanoseal produced a layer of nano-particles on the exposed dentin surface and occluded dentinal tubules even under difficult conditions such as contamination by blood or saliva, dilution with water, and shorter time (3-8 seconds) of application.
B. Clinical evaluation
1. Changes in VAS value: Preoperative mean value was 32.7±22.4 while postoperative mean value was 8.5±9.7. Pain symptoms were significantly improved (paired t-test: p<0.01).
2. Changes in PPI: Preoperative mean score was 1.7±1.0 while postoperative mean score was 0.5±0.5. Pain symptoms were significantly improved (paired t-test: p<0.01).
3. Effectiveness (efficacy) rating: 87 of the 101 cases (86.1%) showed desensitizing efficacy by application of Nanoseal.
4. Safety and operability: No side effects were detected after application of Nanoseal. It was shown that Nanoseal can be easily applied to the gingival sulcus or the adjacent tooth surface, even when wetted by saliva or blood.
Conclusion: These results suggest that Nanoseal showed excellent pain reduction effects, and is safe and useful in the treatment of daily Hys symptoms.
