Effect of combined treatment with hyperthermia and epinephrine of human oral carcinoma transplanted in nude mice

Abstract

We investigated the effect of the combined treatment with hyperthermia and epinephrine of human oral carcinoma (KB cells) transplanted subcutaneously in the leg of BALB/cA nude mice. Intratumoral, intraperitoneal injection of epinephrine alone, and combined treatment with hyperthermia and epinephrine injected intraperitoneally had no beneficial effects. Combined treatment with hyperthermia and epinephrine injected intratumorally seemed to have an inhibitory effect on the growth of the KB cells. The sensitizing effect depended on the concentration of epinephrine. We concluded that combined treatment with hyperthermia and epinephrine injected intratumorally is effective.