Experimental studies on bone formation with apatite-collagen material

Abstract

Various artificial bone graft materials have been developed to augment resorbed alveolar bone to promote denture retention. I studied the effect of octacalcium phosphate with collagen sponge on bone formation in 6 Japanese monkeys. The experimental materials were inserted into defects created in the alveolar bone. Microvascular casts were prepared for scanning electron microscopic observation at 2, 3 and 4 weeks after insertion. This calcium phosphate collagen material promoted the formation of a dense capillary network during the first two weeks, and aided in bone healing. Use of octacalcium phosphate with collagen sponge in alveolar bone defects may promote bone formation in preparation for placement of dentures.